SIFT
A web tool to predict the effect of single nucleotide polymorphism (SNP) on protein function.
Topic
Biology, Genetics, DNA polymorphism
Detail
Operation: Prediction and recognition
Software interface: Command-line interface, web user interface
Language: Perl
License: Freely available to the academic community. Commercial licensees should contact Steven Henikoff.
Cost: -
Version name: -
Credit: Tai Pang Yong, Jorja Henikoff, Lakshmi Radhakrishnan, Anthony Youzhi Cheng, and Qiangze Hoi.
Input: -
Output: -
Contact: https://sift.bii.a-star.edu.sg/sift-bin/contact_sift4g.pl
Collection: -
Maturity: -
Publications
- Predicting the effects of coding non-synonymous.
- Kumar P, et al. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. 2009; 4:1073-81. doi: 10.1038/nprot.2009.86
- https://doi.org/10.1038/nprot.2009.86
- PMID: 19561590
- PMC: -
- SIFT missense predictions for genomes.
- Vaser R, et al. SIFT missense predictions for genomes. SIFT missense predictions for genomes. 2016; 11:1-9. doi: 10.1038/nprot.2015.123
- https://doi.org/10.1038/nprot.2015.123
- PMID: 26633127
- PMC: -
- SIFT: Predicting amino acid changes that affect protein function.
- Ng PC and Henikoff S. SIFT: Predicting amino acid changes that affect protein function. SIFT: Predicting amino acid changes that affect protein function. 2003; 31:3812-4. doi: 10.1093/nar/gkg509
- https://doi.org/10.1093/nar/gkg509
- PMID: 12824425
- PMC: PMC168916
- SIFT web server: predicting effects of amino acid substitutions on proteins.
- Sim NL, et al. SIFT web server: predicting effects of amino acid substitutions on proteins. SIFT web server: predicting effects of amino acid substitutions on proteins. 2012; 40:W452-7. doi: 10.1093/nar/gks539
- https://doi.org/10.1093/nar/gks539
- PMID: 22689647
- PMC: PMC3394338
- Predicting deleterious amino acid substitutions.
- Ng PC and Henikoff S. Predicting deleterious amino acid substitutions. Predicting deleterious amino acid substitutions. 2001; 11:863-74. doi: 10.1101/gr.176601
- https://doi.org/10.1101/gr.176601
- PMID: 11337480
- PMC: PMC311071
- Accounting for human polymorphisms predicted to affect protein function.
- Ng PC and Henikoff S. Accounting for human polymorphisms predicted to affect protein function. Accounting for human polymorphisms predicted to affect protein function. 2002; 12:436-46. doi: 10.1101/gr.212802
- https://doi.org/10.1101/gr.212802
- PMID: 11875032
- PMC: PMC155281
Download and documentation
Documentation: https://sift.bii.a-star.edu.sg/sift4g/AboutSIFT4G.html
Home page: http://sift-dna.org/
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