SIFT

A web tool to predict the effect of single nucleotide polymorphism (SNP) on protein function.

Topic

Biology, Genetics, DNA polymorphism

Detail

  • Operation: Prediction and recognition

  • Software interface: Command-line interface, web user interface

  • Language: Perl

  • License: Freely available to the academic community. Commercial licensees should contact Steven Henikoff.

  • Cost: -

  • Version name: -

  • Credit: Tai Pang Yong, Jorja Henikoff, Lakshmi Radhakrishnan, Anthony Youzhi Cheng, and Qiangze Hoi.

  • Input: -

  • Output: -

  • Contact: https://sift.bii.a-star.edu.sg/sift-bin/contact_sift4g.pl

  • Collection: -

  • Maturity: -

Publications

  • Predicting the effects of coding non-synonymous.
  • Kumar P, et al. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. 2009; 4:1073-81. doi: 10.1038/nprot.2009.86
  • https://doi.org/10.1038/nprot.2009.86
  • PMID: 19561590
  • PMC: -
  • SIFT: Predicting amino acid changes that affect protein function.
  • Ng PC and Henikoff S. SIFT: Predicting amino acid changes that affect protein function. SIFT: Predicting amino acid changes that affect protein function. 2003; 31:3812-4. doi: 10.1093/nar/gkg509
  • https://doi.org/10.1093/nar/gkg509
  • PMID: 12824425
  • PMC: PMC168916
  • SIFT web server: predicting effects of amino acid substitutions on proteins.
  • Sim NL, et al. SIFT web server: predicting effects of amino acid substitutions on proteins. SIFT web server: predicting effects of amino acid substitutions on proteins. 2012; 40:W452-7. doi: 10.1093/nar/gks539
  • https://doi.org/10.1093/nar/gks539
  • PMID: 22689647
  • PMC: PMC3394338
  • Predicting deleterious amino acid substitutions.
  • Ng PC and Henikoff S. Predicting deleterious amino acid substitutions. Predicting deleterious amino acid substitutions. 2001; 11:863-74. doi: 10.1101/gr.176601
  • https://doi.org/10.1101/gr.176601
  • PMID: 11337480
  • PMC: PMC311071
  • Accounting for human polymorphisms predicted to affect protein function.
  • Ng PC and Henikoff S. Accounting for human polymorphisms predicted to affect protein function. Accounting for human polymorphisms predicted to affect protein function. 2002; 12:436-46. doi: 10.1101/gr.212802
  • https://doi.org/10.1101/gr.212802
  • PMID: 11875032
  • PMC: PMC155281

Download and documentation


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