ALRA

ALRA (Adaptively-thresholded Low Rank Approximation) is a tool for genotype imputation. The ALRA algorithm uses a low-rank approximation method to capture expressed gene dropouts. ALRA is also integrated into Seurat v3.0.

Topic

Population genetics;Transcriptomics;Gene expression

Detail

  • Operation: Imputation

  • Software interface: Command-line user interface;Library

  • Language: R

  • License: The MIT License

  • Cost: Free

  • Version name: -

  • Credit: The National Institutes of Health (NIH)

  • Input: scRNA-seq expression matrix

  • Output: -

  • Contact: Yuval Kluger yuval.kluger@yale.edu

  • Collection: -

  • Maturity: Emerging

Publications

  • Zero-preserving imputation of scRNA-seq data using low-rank approximation
  • Kaushik A, et al. miRMOD: a tool for identification and analysis of 5' and 3' miRNA modifications in Next Generation Sequencing small RNA data. miRMOD: a tool for identification and analysis of 5' and 3' miRNA modifications in Next Generation Sequencing small RNA data. 2015; 3:e1332. doi: 10.7717/peerj.1332
  • https://doi.org/10.1101/397588
  • PMID: -
  • PMC: -

Download and documentation


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